Posted by SLS on February 16, 2014, at 18:49:18
In reply to Lurasidone, posted by Bob on February 16, 2014, at 14:10:54
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> I'm starting to lose faith in lurasidone (Latuda). I've been on it for about 6 weeks now and all the uplifting and energizing effects I had on startup are long gone and now it only seems to be producing a slight malaise. About 30-60 minutes after a dose I feel more depressed and tired. I wears off for the most part after that but any benefits seem to be gone. I was looking for an antidepressant/energizing effect but it has not persisted.
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> -BobYou could try cutting back to 20 mg/day. I might do this myself as an experiment. Since the binding affinity of lurasidone for 5-HT7 receptors is higher than it is for NE alpha-2 receptors, I am hoping that at very low dosages, 5-HT7 blockade will occur with little or no NE alpha-2 blockade.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1060756
URL: http://www.dr-bob.org/babble/20140214/msgs/1060766.html