Posted by SLS on January 3, 2014, at 20:57:02
In reply to Re: Sorry... » SLS, posted by mogger on January 3, 2014, at 20:36:14
> I never have Scott. I tried Wellbutrin about 15 years ago at University well before Lamictal but I remember getting anxiety from Wellbutrin. I wonder if Remeron (I recently went to 45mgs) has the same metabolite as Seroquel as I know they both have norepinephrine properties. I am loathe to try Abilify as I know from your experience you have had trouble with weight gain correct? I was on Zyprexa and only gained a few pounds. Seroquel has actually made me lose weight. But I shouldn't disregard something before I try it.
Wellbutrin can exacerbate anxiety. I really wasn't thinking about your OCD. I imagine Wellbutrin can make it worse in some people. I was hoping to come up with a way to boost the clinical effect of Lamictal using a dopaminergic agent. Abilify does a nice job of stabilizing DA synaptic activity.
Perhaps the place to start is to try adding nortriptyline. It is primarily a norepinephrine reuptake inhibitor, as is the active metabolite of Seroquel. Nortriptyline might allow you to keep the dosage of Seroquel to 150 mg/day or perhaps even allow you to discontinue it entirely. Notriptyline goes well with just about anything, including MAOIs. Come to think of it, I don't think I ever saw nortriptyline added to Wellbutrin. I wouldn't think that it would be a high-percentage treatment. Seroquel acts more like nortriptyline than does Remeron. The mechanism by which Remeron increases synaptic NE concentrations is NE alpha-2 receptor blockade. If you bring in nortriptyline, you might be able to swap out the Seroquel for Latuda. You would lose nothing and gain 5-HT7 antagonism.
There is some evidence that adding Abilify to an SSRI can improve OCD.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1057574
URL: http://www.dr-bob.org/babble/20131209/msgs/1057707.html