Posted by phidippus on December 30, 2013, at 14:46:51
In reply to Tardive Dyskensia/antidepressents, posted by lazylizard on December 9, 2013, at 18:31:13
Currently, the only approved drug for treating tardive dyskinesia and other movement disorders is tetrabenazine, which is a dopamine depleting drug. The related VMAT2 inhibitor, reserpine, has also been tried in one small randomised double-blind placebo-controlled trial as a treatment for TD with success, as has α-methyldopa. Ondansetron (Zofran) has shown some benefit in experimental studies on tardive dyskinesia and a variety of anti-Parkinsonian medications are used such as donepezil, baclofen, and pramipexole. Clonidine may also be useful in the treatment of TD, although dose-limiting hypotension and sedation may hinder its usage.Botox injections are used for minor focal dystonia, but not in more advanced tardive dyskinesia.Benzodiazepines are an effective treatment for TD, however their use is limited by the development of tolerance which requires ever increasing doses of the benzodiazepines to be used to attenuate TD symptoms. The most popular benzodiazepine for the treatment of TD is clonazepam. Vitamin B6 has been reported to be an effective treatment for TD in two randomised double-blind placebo-controlled trials. In males, the branched-chain amino acid formula Tarvil, containing the amino acids valine, isoleucine, and leucine in a 3:3:4 ratio was reported as beneficial for motor symptoms in a small, non-blinded study.
Eric
poster:phidippus
thread:1055828
URL: http://www.dr-bob.org/babble/20131209/msgs/1057207.html