Hi Ed! :-)
I tried lansoprazole first (30mg) and 10 days later had the fever, tachycardia and bone pain for about 12 hours. I tried a rechallenge with it later and the reaction occurred 3 days later. Next time it happened nearly the same day if I remember correctly.
I tried omeprazole 3 years later in small amounts by emptying out a capsule and taking small pieces every hour or so. I started getting sharp pains that would be felt randomly in different parts of the body (in the bones.. ribs, arms, legs.. everywhere there was a bone).
Interestingly, I had the same reaction with diet soda that contained cyclamate and saccharin. Fever, bone pain and tachycardia for about 12 hours.
I found that these drugs are all sulphonamides or sulfur compounds when metabolised.
Maybe I have some sort of hypersensitivity to sulphonamides or substituted benzimidazoles (PPIs), although PPIs also break down into sulfur-like compounds when they reach the stomach.
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this signature | Show by default | Change to hide (next time)alprazolam 1mg QID, famotidine 40mg QID, cetirizine 10mg BID, GNC Ultra Mega Gold 1x/day, Vitamin D 1200IU, probiotics, quit smoking 19/4/2013
Dx: panic disorder with agoraphobia, OCD