Posted by ed_uk2010 on December 3, 2013, at 13:04:16
In reply to Re: Safest tricyclics?, posted by Lamdage22 on December 3, 2013, at 8:58:45
>Lexapro can prolong QT interval.
True, but probably less so than any of the major tricyclics. Overall, it seems that tricyclics are considerably more likely to cause cardiac arrhythmias than other ADs, including all SSRIs. QT prolongation is dose-dependent, so anyone at risk should avoid high doses and overly complex med combinations.
Amitriptyline in particular tends to cause QT prolongation, which is part of the reason that it is very toxic in overdose.
poster:ed_uk2010
thread:1054839
URL: http://www.dr-bob.org/babble/20131115/msgs/1055346.html