Posted by linkadge on November 27, 2013, at 20:25:44
In reply to Re: Quinolinic acid and suicide attempts, posted by Hugh on November 27, 2013, at 12:11:21
Certain anti-inflamatories may not be suitable for long term treatment of depression. Regular use of aspirin and ibuprofen etc. can kill of good bacteria in the gut which might worsen depression. (Probiotics apparently can help certain types of depression.)
Its probably also important to determine the cause of the inflamation. Sugar, stress, bad oral hygine, lack of sleep, lack of exercise, have been apparently linked to inflamation. Inflamation might simply be a response to a perceived stressor. Blocking the inflamation might treat the symptoms of the depression but not the source. Antidepressants and lithium apparently have immune modulating effects. I think activating the 5-ht1a receptor reduces inflamation.
The enzyme gsk-3b (modulated by certain antidepressants and lithium) regulates neural inflamation as well as circadian rythem. This enzyme has been linked to certain mood disorders.
Its an interesting piece to the puzzle though.
Linkadge
poster:linkadge
thread:1054923
URL: http://www.dr-bob.org/babble/20131115/msgs/1055001.html