Re: minocycline on glutamate? » Jeroen

Posted by doxogenic boy on October 26, 2013, at 16:07:01

In reply to minocycline on glutamate?, posted by Jeroen on October 23, 2013, at 15:53:37

> does mino work on glutamate?
It probably does. Here are two abstracts about this:
http://www.ncbi.nlm.nih.gov/pubmed/22486246
Excerpt from the link above:
CNS Drugs. 2012 May 1;26(5):391-401. doi: 10.2165/11632000-000000000-00000.
Minocycline: therapeutic potential in psychiatry.
Dean OM, Data-Franco J, Giorlando F, Berk M.
Source
Deakin University, School of Medicine, Barwon Health, Geelong, VIC, Australia. oliviad@barwonhealth.org.au
Abstract
Pharmacological interventions to treat psychiatric illness have previously focused on modifying dysfunctional neurotransmitter systems to improve symptoms. However, imperfect understanding of the aetiology of these heterogeneous syndromes has been associated with poor treatment outcomes for many individuals. Growing evidence suggests that oxidative stress, inflammation, changes in glutamatergic pathways and neurotrophins play important roles in many psychiatric illnesses including mood disorders, schizophrenia and addiction. These novel insights into pathophysiology allow new treatment targets to be explored. Minocycline is an antibiotic that can modulate glutamate-induced excitotoxicity, and has antioxidant, anti-inflammatory and neuroprotective effects.
End quote.
http://www.ncbi.nlm.nih.gov/pubmed/24139854
Excerpt from the link above:
Epilepsy Res. 2013 Oct 1. pii: S0920-1211(13)00246-5. doi: 10.1016/j.eplepsyres.2013.09.006. [Epub ahead of print]
Minocycline exerts acute inhibitory effects on cerebral cortex excitability in humans.
Lang N, Rothkegel H, Terney D, Antal A, Paulus W.
Source
Department of Neurology, Christian-Albrechts-University, UKSH, Arnold-Heller-Str. 3 (Haus 41), 24105 Kiel, Germany; Clinic for Clinical Neurophysiology, Georg-August-University, Robert-Koch-Straße 40, 37079 Göttingen, Germany. Electronic address: n.lang@neurologie.uni-kiel.de.
Abstract
Minocycline has efficacy to alleviate seizure activity in animal models of epilepsy. Among other mechanisms it has been postulated that minocycline can inhibit microglial activation and develop beneficial effects by decreasing glutamate excitotoxicity.
End quote.
- doxogenic
Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine

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minocycline on glutamate? Jeroen 10/23/13
Re: minocycline on glutamate? » Jeroen Phillipa 10/23/13
Re: minocycline on glutamate? » Jeroen doxogenic boy 10/26/13

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