Posted by doxogenic boy on October 23, 2013, at 3:24:08
In reply to Re: Augmenting Luvox/SSRIs in general...I'm a newbie!, posted by Rahilka on October 22, 2013, at 21:47:59
> Thanks for the suggestion, Doxogenic! When I was hospitalized I was given a really low dose of Seroquel at night (25 mg) for insomnia. For that, it was absolutely amazing.
>
> I wonder though if it would make me feel even more sedated on the Luvox since it is already so tranquilizing...?That could happen, but it is difficult to say. Since you have GAD, OCD and SAD, stimulating antidepressants could worsen your anxiety. Seroquel can help for treatment-resistant depression in combination with SSRIs.
Here is a study showing that an antypical antipsychotic works against SSRI-induced apathy. It is about long-term use of SSRIs, though.
http://www.ncbi.nlm.nih.gov/pubmed/12019662
Excerpt from the abstract above:J Clin Psychiatry. 2002 May;63(5):391-5.
Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: an open-label, flexible-dose study.
Marangell LB, Johnson CR, Kertz B, Zboyan HA, Martinez JM.
SourceMood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Houston, Tex 77030, USA. laurenm@bcm.tmc.edu
Abstract
BACKGROUND:We report a clinical trial of olanzapine in the treatment of prominent apathy in the absence of depression in patients on long-term treatment with selective serotonin reuptake inhibitors (SSRIs) for nonpsychotic major depression.
[...]
CONCLUSION:These preliminary data suggest that olanzapine may be effective in treating apathy syndrome in nonpsychotic patients taking SSRIs.
End quote.>I hope this mental lethargy goes away on a higher dose even though I have to wait THREE WEEKS just to go up! I think my doctor may be titrating me up on meds wayyyy too slowly...
Some Luvox users can get nausea and vomiting if they titrate too fast and start with a high dose. Maybe this is a reason why your doctor is titrating you so slow.
Seroquel (quetiapine) can work for sleep quality in GAD:
http://www.ncbi.nlm.nih.gov/pubmed/24135509
Quote from the link above:
J Affect Disord. 2013 Aug 16. pii: S0165-0327(13)00608-3. doi: 10.1016/j.jad.2013.07.037. [Epub ahead of print]
Effects of extended-release quetiapine fumarate on long-term functioning and sleep quality in patients with Generalized Anxiety Disorder (GAD): Data from a randomized-withdrawal, placebo-controlled maintenance study.
Sheehan DV, Svedsäter H, Locklear JC, Eriksson H.
SourceUniversity of South Florida College of Medicine, Tampa, FL 33613, USA. Electronic address: dsheehan@health.usf.edu.
Abstract
BACKGROUND:This analysis evaluated effects of quetiapine XR maintenance treatment on functioning and sleep in patients with GAD.
[...]CONCLUSIONS:
In patients with GAD, long-term treatment with quetiapine XR (50-300mg/day) monotherapy was effective at maintaining improvements in functioning and sleep quality.
End quote.- doxogenic
Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine
poster:doxogenic boy
thread:1052613
URL: http://www.dr-bob.org/babble/20130930/msgs/1052848.html