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MAOI is diminishing stimulant effectiveness?

Posted by John Q P on October 5, 2013, at 14:49:57

Diagnoses: Atypical Depression (hypersomnia, hyperphagia), ADHD-PI, "numerous traits associated with Aspergers" (neuropsych eval)

Essentially the only things that work are stimulants... And Vyvanse > Adderall. While scaling up doses... no matter the dose, the effects were the same... Just the duration was longer. At 70mg Vyvanse, that window is about 6 hours.

During those 6 hours I'm myself and it's great... Around 6 hours my cognitive functioning declines and shortly thereafter so too does my mood, followed by return to my baseline drowsiness/fatigue/brain fog/sleepiness.

After many failed attempts at augmentation my psych and I are now trying Vyvanse 70 with Emsam 6mg/24. The biggest benefit: I can finally wake up in the morning and go to sleep at normal times. Downsides? It somehow worsened my baseline mood (almost sorrow or dysphoric) and Vyvanse no longer does anything.


So I tried lowering the Vyvanse dose to see if I was overdosing. Nope, nothing. The[n] I tried carefully increasing Vyvanse dose (while checking BP). My internal "lightswitch" turned back on and it was effective again.

So wtf? Anyone with MAOI experience able to decipher what is going on?


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poster:John Q P thread:1051758
URL: http://www.dr-bob.org/babble/20130930/msgs/1051758.html