Posted by SLS on October 4, 2013, at 6:22:56
In reply to still feeling bad on Riluzole, posted by g_g_g_unit on September 22, 2013, at 5:37:51
> sorry to drone on, but I increased my dose to 100mg a day a little over a week ago and am still feeling very anxious, irritable and am having trouble sleeping.
>
> I feel stubborn and stupid clinging on, as I did the same thing with memantine for 3 pointless months, but I guess I can't face the prospect of it not working.
>
> is there any sense in thinking this stuff might pass?
>
> I'm going to ask my doctor for a Prazosin script tomorrow to hopefully help sleep/take the edge off, so I can at least hold out longer, but I feel so unbearably frustrated, angry and distraught over this whole thing.For me, it seems that a combination of Minocycline + Lamictal has modulated excessive glutamate activity. I also take Abilify.
I was very disappointed by riluzole. It didn't help at all. However, one cannot deduce from this that glutamate dysfunction is not contributing to depression and anxiety.
Have you ever tried Navane (thiothixine) or Phenergan (promethazine) for your anxiety?
Prazosin is an interesting choice. Recent studies use 20 - 30 mg/day in divided doses. Despite the use of these higher dosages, one must nonetheless begin treatment using a single 1.0 mg dose given at night and follow up 2.0 - 3.0 mg. Even at this low dosage, temporary dizziness often occurs, so a gradual titration is recommended.
Is there any history of trauma?
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1051113
URL: http://www.dr-bob.org/babble/20130930/msgs/1051682.html