Posted by Lou Pilder on September 17, 2013, at 15:54:44
In reply to Re: Interactions Antiepileptics/Antipsychotics » SLS, posted by doxogenic boy on September 17, 2013, at 14:33:42
> > Thanks for the valuable information!
>
> You're welcome! I think it should be done much more research into interactions with psychotropic drugs.
>
> I find interesting points about interactions in the article "Potentially hazardous drug interactions with psychotropics":
> http://apt.rcpsych.org/content/11/6/440.full
>
> Some quotes from the article:
> Most interactions are harmless and of only theoretical interest.
> [...]
>
> The evidence for many potential interactions is based only on in vitro or animal research, single case reports or small-scale uncontrolled studies
> [...]
>
> For example, enzyme induction by carbamazepine decreases the effectiveness of tricyclic antidepressants and antipsychotics.
> [...]
>
> Much research has been carried out into potentially hazardous interactions with psychotropic drugs, yet there is much that remains unknown. The evidence for some potential interactions is based on animal experiments, isolated case reports in which there is doubt about the cause-and-effect relationships, or small-scale volunteer studies that may not reflect the action of, and interaction between, drugs in patients.
>
> End of quotes.
>
> I haven't thought of before that most drug interactions are harmless, and that knowlegde of (some of) the potential hazardous interactions are based on limited evidence.
>
> - doxogenicFriends,
It is written here, [...most drug interactions are harmless, and that knowledge of (some of)the potential hazardous interactions are based on limited evidence...].
Now I think that you are all the right kind of people and I want to be perfectly frank. You've got one, two three, four, five, six drugs on the table. Drugs that could mark the difference between a live person or a corpse. Did you ever try and sit down as ask if Elvis would be alive if he did not take all those drugs? And how about Anna Nicole Smith and Michael Jackson too?
You see, the citation posted here is from 2005. That is 8 years ago, years when many of these drugs did not have time to be explored for their adverse effects in combination with other drugs.
Now there is a website called ehealthme that cataloged reaction back to 1977 and up to today using millions of reports. The adverse reaction with drug combinations now take on a different perspective than from 2005.
Here is a link to two parts to the site.
Lou
http://www.ehealthme.com
http://www.ehealthme.com/askus
poster:Lou Pilder
thread:1050768
URL: http://www.dr-bob.org/babble/20130828/msgs/1050868.html