Posted by andrewb on August 23, 2013, at 1:09:55
In reply to AMISULPRIDE and BENZOS: what interaction?, posted by neo on July 31, 2013, at 14:31:49
A few thoughts, let me know if there is anything I'm saying that you don't already know:
* amisulpride sometimes provides energy and motivation, but unfortunately I've never heard of that effect lasting. This seems to me to be a dopaminergic effect that tolerance quickly develops for.
* just as benzo.s can prevent tolerance to the stimulating effect of amphetamines, an equivalent interaction might be occurring with you.
*it is generally believed that sedation indicates too high of a dose of ami. When this occurs, you lower the dose to 25 and, if needed, further down to 12.5. If it still causes sedation when used continually at that dose it may not be your ideal medicine. Sedation indicates that the targeted d-2, d-3 auto receptors are full and the excess is going onto the d2, d3 receptors and thus acting like an anti-psychotic. BTW: ami. also acts via serotonin subreceptor 7 and possibly via prolactin.
*Benzo.s can be INCREDIBLY hard to withdraw from. If possible, don't use them. If that isn't possibly use them sporadically or take holidays from them.
poster:andrewb
thread:1048097
URL: http://www.dr-bob.org/babble/20130730/msgs/1049532.html