Posted by orbital on August 15, 2013, at 14:18:58
In reply to More emotional - olanzapine, posted by Zyprexa on August 14, 2013, at 23:05:10
The active ingredient in generics is technically allowed to vary between 20% percent less and 25% more than its brandame equivalent. It's not really supposed to happen but you know how it goes.
IME I sometimes find that I need to take quite a bit more of a generic to achieve the same effect that I receive from the drug's brand name counterpart. This only applies to meds with uncomplicated delivery mechanisms. With olanzapine I basically had to double my dose of .. Teva I think?.. to get the same effects as with Zyprexa. Another one that comes to mind is generic citalopram, I simply had to up my dose.
I've had terrible experiences with stuff with complicated pills such as Teva's version of Wellbutrin XL which I think eventually was recalled and withdrawn?... Brandname Wellby XL was smooth as silk.
I do find brand name to be more effective than generics, but some are prohibitely expensive. Like B2 said maybe it,s due to the fillers and such.
In your case I think I'd just go with the generic you trust and adjust my dose "by feel" until i get the bioequivalence and effect right, keeping in mind that say 20mg of Teva olanzapine is (most likely) not equivalent to zyprexa 20.
Hope this helps!
> I've been switching between zyprexa and generic olanzapine. When I went to generic teva and the next day I found myself getting very almost uncontrolable anger. The same thing happened the last time I was on teva, at 10mg I wanted to go mad and trash the house, and I couldn't get it out of my head. Luckly I didn't. I had lots of ups and downs. Then I went up to 15mg teva and it went away. So month later I wanted to use up the last of my brand pills and for 3 weeks I was doing great, not emotional at all. Very analytical positive straight thought. Did exceptionaly well at work, started getting bigger tips. So I went back on teva. Suddenly I was at work pissed about everything that went wrong in my life. couldn't control the anger. People could tell I'm sure. I was just banging around dishes, yelling in my car just furious, thought I would not get over it. I had many sad, heated and paranoid conversations with people a lot. Started to talk a lot, where on brand I didn't need to talk so much, just do business.
>
> I don't feel psychotic or anything just can't control how I feel. on this generic.
>
> It seems to be petering out now. But I'm much more talkative and emotionaly connected. What should I think about this?
>
> Do I try the other generic again? The last time I was on it I was on 10mg and it was fresh. I remember thinking it was better than the teva. but I stoped it and finished off teva. When I went back on the aurobindo it gave me a dark gloomy out look on the world, kind of scary. So I went back on teva. Been taking teva and zyprexa off and on the whole time since and did well. But now I'm almost out of brand and back on teva at 15mg now since a couple of months. My other question is does olanzapine go bad quickly? And should I try the aurobindo again at a fresh and 15mg pill. Or should I stick with teva? I can't afford the brand at $1000/month and my insurance does not cover it at all!
>
> sincerily
> Zyprexa
poster:orbital
thread:1049050
URL: http://www.dr-bob.org/babble/20130730/msgs/1049090.html