Posted by europerep on July 4, 2013, at 6:55:52
In reply to Re: ECT In Kids, Safe,Effective But Under utilizied » linkadge, posted by SLS on July 3, 2013, at 10:09:45
> If you take even a little too much ketamine, you forfeit the antidepressant effect.
Where did you read that? I've read reports from people who were suffering from depression and took recreational doses of ketamine, and got a strong antidepressant effect lasting for several days. And, at the time of using, these people didn't even know that ketamine was studied for potential antidepressant properties.
I think that the question of getting the right dose of ketamine is mostly, if not entirely, related to the psychedelic effects it produces at high(er) doses. After all, the pretty much universally used dosage of 0.5mg/kg, administered over 40 min. via IV infusion, has, at least as far as I know, not been "developed" or elaborated in any kind of way. It's just the dosage the first guys who studied ketamine in TRD came up with, and they sticked with it because it worked. It would be quite a coincidence if they had just accidentally found a "narrow therapeutic window."
poster:europerep
thread:1046274
URL: http://www.dr-bob.org/babble/20130617/msgs/1046397.html