Posted by SLS on June 26, 2013, at 7:24:07
In reply to Re: Bipolar DX based only on SSRI hypomanic response? » SLS, posted by antennastoheaven on June 25, 2013, at 17:43:18
I still have the impression that the rate of suicide caused by treatment with lamotrigine is not much higher than it is with placebo or with some of the other AEDs. I base this on personal observation - not very scientific, I know. However, I have no logical reason to exclude the possibility that a depressive reaction to lamotrigine can occur.
I found the following article. I thought it was balanced, and was written subsequent to those that you cited. That said, I see that there are some reports of suicidality associated with lamotrigine treatment on CrazyMeds. Anecdotes have their value, especially when it happens to you. I reacted pretty badly to gabapentin and pregabalin. I wasn't suicidal per se, but I experienced severe brain fog and derealization. I suppose that if I were closer to committing suicide prior to treatment with these drugs, my untoward reaction to them might have pushed me over the edge. I think many would agree that valproate can exacerbate depression. One person on Psycho-Babble recently reported having a depressive reaction to oxcarbazepine. At this juncture, I think it is prudent to warn doctors and patients of the possibility of adverse reactions on mood from AEDs. However, this should be considered a class effect rather than a commentary on each drug specifically.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132858/
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1045773
URL: http://www.dr-bob.org/babble/20130617/msgs/1045919.html