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Re: Experimental AD Moves Closer To Approval

Posted by SLS on May 21, 2013, at 18:48:29

In reply to Re: Experimental AD Moves Closer To Approval, posted by SLS on May 21, 2013, at 18:35:13

Vortioxetine is quite a bit different from other SSRIs. I think it deserves to be treated seriously as a potential treatment. For each new drug that becomes available, a certain percentage of previously treatment-resistant patients will go on to respond to it.


- Scott

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Dual mechanism of action

Vortioxetine displays two complementary mechanisms of action in vitro: inhibition of serotonin reuptake and modulation of serotonin receptor activity. In addition to blocking the serotonin transporter protein, vortioxetine acts as antagonist at 5-HT3 and 5-HT7 receptors, a partial agonist at 5-HT1B receptors and an agonist at 5-HT1A

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poster:SLS thread:1044014
URL: http://www.dr-bob.org/babble/20130501/msgs/1044059.html