Posted by SLS on May 12, 2013, at 7:08:21
In reply to Scott what dosage?, posted by Lamdage22 on May 12, 2013, at 4:43:31
> Hey Scott,
>
> what dosage for the minocycline?The dosage of minocycline most often studied for depressive and schizoid disorders is 200 mg/day.
Because you responded so well to Lamictal, I think you should think seriously about combining it with minocycline. The combination might work together to produce a greater degree of antiglutamatergic effect.
Minocycline:1. Is neuroprotective.
2. Reduces brain inflammation
3. Reduces the number of glutamate receptors.
4. Demonstrates antidepressant properties in mouse models of depression.
5. Is reported to act synergistically with noradrenergic antidepressants to treat depression - desipramine (but not fluoxetine).
6. Is reported to act synergistically with NMDA antagonists.
7. Reduces glutamate excitotoxicity by reducing the formation of quinolic acid, a NMDA agonist.
8. Reduces mitochondrial release of cytochrome C.
9. Modulates several signaling pathways.
10. Reduces microglial activation.
11. Has been reported anecdotally to successively treat depression.
12. Reduces the expression of lipopolysaccharide-induced pro-inflammation cytokines, an effect that acts as an antidepressant in animal models.
13. Increases neurite growth in response to nerve growth factor (NGF).
14. Inhibits high levels of PKC and GSK-3 alpha;
15. Decreases nitric oxide synthetase, thereby reducing free radicals which damage neurons and glia.
16. Reduces glutamate release.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1042793
URL: http://www.dr-bob.org/babble/20130501/msgs/1043540.html