Posted by Tyrannosaur on April 25, 2013, at 17:30:00
In reply to Re: MAOI + Ginkgo Biloba, posted by vanvog on April 25, 2013, at 6:20:29
> Nortriptyline is a Tricyclic (TCA). I guess Wellbutrin is technically an NDRI. There are selective NRIs like Reboxetine and Atomoxetine (Strattera) which according to Gillman are quite safe with MAOIs. As for TCAs you have so many options, just search for it on babble and you will find many reports on all kinds of combos of TCAs with MAOIs. Of all TCAs only clomipramine and imipramine are NOT SAFE. Basically you can try any other antidepressant which does NOT have SRIs properties, things like mirtazapine, trazodone and actually anything else except an SNRI/SSRI.
>
> What's your current MAOI dose? I'm on 120 mg/day of Parnate myself. How did Wellbutrin worked in the cocktail for you, I wanted to start a trial but my supply is limited and I would not like to waste it for nothing.
>
>Actually i meant Nardil, but for unknown reason i must've typed Parnate. Wellbutrin is indeed marketed for its dopamine action. But I've also read that its effect on dopamine is pretty much negligible, and that it mainly acts as a NRI.
The reason i ask is because MAOIs tend to release octopamine which in fact lowers norepinephrine, despite that MAOIs also blocks the breakdown of norepinephrine. This could be countered with a NRI, but most doctors are not keen on combining meds with MAOIs, according to their literature most TCAs and Bupropion is contraindicated. Despite that many clinical trials and prominent psychiatrists like Ken Gillman for example say otherwise.
So i wanted to hear if there are other NRIs out there that could be combined with MAOIs. (If my doctor won't like the idea of adding Bupropion or TCAs)
poster:Tyrannosaur
thread:1042572
URL: http://www.dr-bob.org/babble/20130408/msgs/1042656.html