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Re: Irritability

Posted by Hugh on April 6, 2013, at 18:43:48

In reply to Re: Irritability » Hugh, posted by brynb on April 6, 2013, at 17:50:41

> Hugh,
>
> Does Baclofen work similarly to Neurontin? I didn't think so, as I thought Neurontin didn't actually work on GABA. I only ask because Neurontin makes me textbook manic, and I'd hate to risk that reaction with Baclofen.
>
> Thanks,
> b

I took Neurontin for about a month at a very low dose and it didn't make me manic, but nothing ever has. It made me feel calm and, after a while, depressed. Baclofen didn't make me feel wired, but very positive and alert, even at 3:00 am after taking 10 mg of Ambien. Ambien normally knocks me out, but it didn't make a dent in baclofen, and I had been up for over fifty hours straight when I decided I had to stop taking it. Until this point, baclofen had given me one of the best weeks of my life.

I know that Neurontin has something to do with GABA, but I don't think they're sure how it works. According to Olivier Ameisen, baclofen and GHB are the only two GABA-B agonists.

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URL: http://www.dr-bob.org/babble/20130322/msgs/1041796.html