Posted by former poster on March 30, 2013, at 23:45:20
In reply to Re: NAC and fatigue?, posted by Emme_V2 on March 30, 2013, at 6:31:44
I heard about the hypoxia side effect from at least 2 different sources, but all I could find right now is this little paragraph from Wikepedia:
http://en.wikipedia.org/wiki/Acetylcysteine#Adverse_effects
Researchers at the University of Virginia reported in 2007 study using very large doses in a mouse model that acetylcysteine could potentially cause damage to the heart and lungs.[31] They found that acetylcysteine was metabolized to S-nitroso-N-acetylcysteine (SNOAC), which increased blood pressure in the lungs and right ventricle of the heart (pulmonary artery hypertension) in mice treated with acetylcysteine. The effect was similar to that observed following a 3-week exposure to an oxygen-deprived environment (chronic hypoxia). The authors also found that SNOAC induced a hypoxia-like response in the expression of several important genes both in vitro and in vivo.
The implications of these findings for long-term treatment with acetylcysteine have not yet been investigated. The dose used by Palmer and colleagues was dramatically higher than that used in humans;[31] nonetheless, positive effects on age-diminished control of respiration (the hypoxic ventilatory response) have been observed previously in human subjects at more moderate doses.[32]
poster:former poster
thread:1040953
URL: http://www.dr-bob.org/babble/20130322/msgs/1041410.html