Posted by SLS on March 20, 2013, at 7:08:25
In reply to Re: Parnate Therapeutic Effect and MAOI Inhibition, posted by vanvog on March 19, 2013, at 21:38:19
> My point is, we don't know how MAO inhibitors work for the most part.
Can't the same be said of other antidepressants?
> There might be many contributing mechanisms other than MAO inhibition itself so the reasoning "you have to take dose x to achieve inhibition of x%" which I came across on Psycho-Babble might be too simplistic or even wrong.
I don't recall there being a consensus established on behalf of Psycho-Babble promoting a mechanism of action for MAOIs.
What is the accepted value for the minimum percentage of MAO inhibition deemed necessary for producing a clinical response?
> I see it as an argument for higher doses in general because it appears to be that you get decent % of inhibition with very low doses.
Can you cite specific drugs and specific values?
> There might be other mechanisms we don't know about yet which kick in on significantly higher doses than 60 mg/day.
It has been a long time since I had my MAO activity assayed. I'm not sure that this is done anymore. At 60 mg/day, my MAO was about 90% inhibited. At that time, I responded well to 60 mg/day, but relapsed at 50 mg/day.
I have seen animal studies indicating that at high dosages, but not low dosages, Parnate downregulates 5-HT2a receptors and reduces tryptamine binding in the hippocampus and striatum.
http://www.ncbi.nlm.nih.gov/pubmed/7931218
http://www.ncbi.nlm.nih.gov/pubmed/8139763
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1040654
URL: http://www.dr-bob.org/babble/20130308/msgs/1040707.html