Posted by SLS on February 1, 2013, at 2:23:03
In reply to Re: My Anxiety - the end of the road - SLS, posted by jono_in_adelaide on January 31, 2013, at 18:54:55
> I've decided to try the nortriptyline route first - drop the reboxetine and add nortriptyline.
>
> Hopefully the 5HT2A antagonist effect will help the anxiety and the NARI activity will maintain the antidepressant effect.
>
> If this avenue doesnt work, then i guess I'll try dropping sertaline and adding mirtazapine, and see where that leads
>
> If that turns out to be a dead end, there is always nardil, wht GABA activity of which interests me greatly
Good luck!There will be a whole lot of us rooting for you.
I like the idea of Nardil. You might even be able to tolerate it in combination with nortriptyline.
It is too bad that vigabatrin (Sabril) can cause irreversible damage to vision. It is a potent GABA transaminase inhibitor. I have heard that lemon balm can inhibit this enzyme, as well as valproate. Tiagabine (Gabitril) is a GABA reuptake inhibitor. It is unpredictable, though. It is anxiolytic in some people and agitating in others
There is some evidence that gabapentin increases the rate of rate of synthesis of GABA via glutamic acid decarboxylase. Some people experience a sustained anxiolytic effect at low dosages (600 - 900 mg/day). I react badly to it, though. Both gabapentin and pregabalin affect me the same way. They make my depression worse and produce cognitive impairments that can last for weeks after discontinuation. I attribute this to its interaction with the alpha2delta subunit of the calcium channel. Of course, not everyone experiences this.
Like I said, you'll figure it out.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1036804
URL: http://www.dr-bob.org/babble/20130124/msgs/1037038.html