Posted by metamorphosis on December 30, 2012, at 14:24:30
Effexor, being an SNRI, affects 5HT and norepinephrine through reuptake inhibition.
Remeron is a noradrenergic and specific serotonergic antidepressant. It is a tetracyclic antidepressant.Remeron is interesting in it's sedating effects. This side effect is paradoxical. Lower doses (7.5-15mg) increase sedation. While at higher doses (30-45mg)sedation decreases.
The sedative effect of mirtazapine at low doses is consistent with its high affinity for the histamine-1 receptor.
While higher doses of mirtazapine result in the blockade of the alpha-2 adrenergic receptor, which produces an alerting or arousal effect.
Remeron focuses most of the serotonin action on 5TH1A receptors, blocks 5HT2A, 5HT2C & 5HT3. The enhancement of adrenergic neurotransmission increases the amount of serotonin your brain produces, and indirectly does the same for norepinephrine. It also speeds up the rate at which those neurotransmitters hit their receptors.Here are some studies on not only it's anti-depressant effects, but also as an ant-anxiety med.
http://www.ncbi.nlm.nih.gov/pubmed/20531012
http://www.ncbi.nlm.nih.gov/pubmed/18225507
poster:metamorphosis
thread:1034220
URL: http://www.dr-bob.org/babble/20121217/msgs/1034220.html