I have been home for three days, and I continue to feel significantly better. Apparently, the increase in the dosage of prazosin allowed me to discontinue the minocylcine while maintaining an antidepressant response. I do believe that minocycline can produce a robust therapeutic response based upon my rapid improvement upon its introduction. However, I cannot attest to its persistence of effect.
From what I have learned recently, I am thinking that combining three different substances that modulate glutamatergic neurotransmission might work synergistically to produce an antidepressant response:
1. Lamictal
2. Minocycline
3. N-acetylcysteine (NAC)
Berk M, et al. recently reported that NAC is more effective than placebo when treating both unipolar and bipolar depression. Post RM commented that it was his belief that the glutamatergic properties of NAC were more important than its antioxidant properties for its exerting an antidepressant effect. It can take as long as three months for NAC to produce results.
- Scott
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this signature | Show by default | Change to hide (next time)Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw