Posted by linkadge on November 3, 2012, at 18:52:27
In reply to Re: intranasal Flumazenil VS intraveinous, posted by poser938 on November 3, 2012, at 13:17:06
Your low dopamine (if this is even the problem) may not be related to elevated gaba.
Other possible (numerous) factors causing / resembling diminished dopamine function include:
- poor dopamine synthesis (genetic)
- deficiancy in dopamine precursors or co-factors
- altered metabolic homeostasis (MAO, COMT, DAT)
- diminished p11 (5-ht1b) receptor expression
- elevated acetylcholine (at muscarinic receptors)
- diminished acetlycholine (at nicotinergic receptors)
- enhanced rem sleep
- elevated cortisol
- elevated glutamate (diminished NMDA gating)
- lowered d2 expresssion or sensitivity (fatty acid imbalance / deficiancy)
- elevated 5-ht2c inhibitory expression
- elevated serotonergic activity at 5-ht2c
- diminished cannabanoid signaling (cb1)
- diminished cannabanoid synthsis / metabolism
- diminished opioid receptor signalling
- reduced GDNF expression
- reduced BDNF expression
- diminished PKC activity
- diminished 2nd mesenger signaling (inositol)
- diminished GSK-3b expression
- undermethylation (SAMe deficiancy)
- vitamin deficiancy (ie b6, b12, vitamin d, iron)
- diminished antioxidant status
- inflamation
- testosterone deficiancy
- growth hormone deficancy
- DHEA deficiancy
- subclinical insulin resistance
- phenylethylamine deficiancy
- adrenal insufficiancy
- etc, etcOr, your problem might not be related to dopamine at all......
Linkadge
poster:linkadge
thread:1030570
URL: http://www.dr-bob.org/babble/20121029/msgs/1030603.html