Posted by schleprock on October 25, 2012, at 21:33:18
In reply to Re: Nardil pooped out? Switch to Parnate? » schleprock, posted by phidippus on October 25, 2012, at 21:05:48
> Specifically, there is a growing body of evidence that suggests that lithium increases the effect of antidepressants by acting at the presynaptic serotoninergic receptor to up-regulate 5-HT (serotonin) release. The effect may also be linked to a decrease in the sensitivity of presynaptic 5-HT receptors, which results in an increase in the amount of serotonin absorbed at the post-synaptic level.
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> More serotonin!
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> EricWould'nt this establish Lithium as a potential risk for serotonin syndrome when used with an AD (with the AD still being taken at the typical dosage)? If not, then what is it about lithium that would make it different to other SA raising agents that carry this risk.
poster:schleprock
thread:1029620
URL: http://www.dr-bob.org/babble/20121018/msgs/1029797.html