Posted by ChicagoKat on October 17, 2012, at 22:12:39
In reply to Re: For those of you on MAOIs--question » Roslynn, posted by zazenducke on October 17, 2012, at 18:54:54
Thank you zazenducke for posting this. I was aware sublingual nifedipine had been banned and fallen out of practice b/c it was found to be dangerous, but your post gives all the specific reasons why plus the proof of this.
For those on MAOIs who want to carry something with them to help if they should experience a hypertensive crisis, regular immediate release nifedipine does have a fairly quick onset of action at about 20mins. But really, the danger of foods with MAOIs has been overhyped. What's far more dangerous is over the counter cold preparations and the like. These should definitely be avoided.
Kat> Sublingual nifedipine has previously been used in hypertensive emergencies. This was found to be dangerous, and has been abandoned. Sublingual nifedipine causes blood-pressure lowering through peripheral vasodilation. It can cause an uncontrollable decrease in blood pressure, reflex tachycardia, and a steal phenomenon in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death. As a result of this, the FDA reviewed all data regarding the safety and efficacy of sublingual nifedipine for hypertensive emergencies in 1995, and concluded that the practice should be abandoned because it was neither safe nor efficacious.[5][6]
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> http://en.wikipedia.org/wiki/Nifedipine
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> This explains why sublingual nifedipine is not used.
poster:ChicagoKat
thread:1028972
URL: http://www.dr-bob.org/babble/20121009/msgs/1029010.html