Posted by sk85 on September 24, 2012, at 12:20:47
In reply to Re: Boosting ADs with yohimbine » sk85, posted by SLS on September 23, 2012, at 21:24:54
> Hi.
>
> > alpha 2 antagonist can and will increase 5-HT firing
>
> That's very interesting. Where could I find more information about this? Do you know what brain structures or circuits are involved?
>
> Thanks for the link.
>
>
> - ScottIt works through alpha 2 heteroreceptors on serotonin neurons.
http://jpet.aspetjournals.org/content/277/2/861.abstract
In yohimbine's case it could also be due to 5-HT1A partial agonism which leads to densitization and subsequent increase in serotonin levels, much like SSRIs work.
poster:sk85
thread:1026312
URL: http://www.dr-bob.org/babble/20120922/msgs/1026516.html