Posted by SLS on September 23, 2012, at 21:51:35
In reply to Re: Minocycline update., posted by jono_in_adelaide on September 23, 2012, at 21:13:15
> Which symptoms do you feel that the minocycline is helping most Scott?
It definitely helps with cognition and memory. My capacity to read has improved. I can concentrate better. I have more mental energy, although I am still looking for more motivation to initiate activities and socialize, although social anxiety is reduced. Anhedonia has improved somewhat. So has psychomotor retardation.
Obviously, I don't want to take more drugs than is necessary to achieve the goal of remission. I discontinued taking prazosin a few weeks ago hoping that I could avoid the cognitive issues at higher dosages and the decrease in libido that it causes. However, I have decided to reintroduce it in an effort to capture a broader and more robust antidepressant response. I also attempted to discontinue taking Abilify 10 mg/day. I began to deteriorate after being at 5 mg/day for three days, so I went back to my original dosage. Abilify is responsible for raising my triglycerides and increasing my body weight. The one drug that I could probably discontinue successfully is lithium. However, as I have noted in the past, I retain it in my treatment regime in the hopes that it will reduce my risk of contracting Alzheimers Dementia. I think it has subtle effects to reduce mood drift, but I am not sure this would continue to be a problem with the minocycline aboard.
If I do improve further with the addition of prazosin, I will ask my doctor to try doxazosin as a replacement for for it because it produces a much more consistant blood level. Prazosin has a half life of only 3 hours. Doxazosin has a half life of 22 hours.
I guess that's more information than you asked for.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1026350
URL: http://www.dr-bob.org/babble/20120922/msgs/1026474.html