Posted by ChicagoKat on September 20, 2012, at 15:04:37
In reply to Re: Nardil is f*ck*ng me, WHAT CAN I DO!!!!!!!!!!, posted by enndub on September 20, 2012, at 13:28:59
> > > > At 60 mg (3.5 weeks) I felt like sh*t, my mood sucked, started getting some anxiety..
> > > >
> > > > I dropped it 9 days ago and went back on 45 mg (45 mg makes me have mild depression and mild anxiety, very easy to handle personally).
> > > >
> > > > FOR SOME REASON, AFTER 9 DAYS I STILL HAVE SH*T 60 MG SIDE EFFECTS, MY MOOD SUCKS AND I HAVE THIS ANXIETY THAT STARTS 2 HOURS AFTER I WAKE UP.
> > > >
> > > > WTF IS GOING ON. WHEN WILL THE 60 MG CONCENTRATION GTFO OF MY BODY, I HAVE THINGS TO DO LATER THIS MONTH (28th,29th,30th).
> > > >
> > > > AHHHHHHHH
> > >
> > > I think you are right; that the enzymes that were inhibited when you were on the higher dose of 60mg will need time to become uninhibited. I have no idea how long this will take. Also, I hate to say it, things may not change even though you've lowered the dose a bit...Nardil is a drug that is relatively rapidly increased in dose so that the enzymes can more quickly become inhibited, thus leading to a quicker therapeutic effect. Once this higher dose/therapeutic effect is reached, many docs decrease the dose to handle the newly formulated enzymes, knowing that the bulk of the existing enzymes is inhibited. So a decrease from 60mg to 45mg may have little impact. I hope this makes sense. Just ask if you have questions.
> > >
> > > The main thing is I am so sorry you are going through hell. Have you talked to your doctor? Maybe Nardil is not the answer for you. At any rate, hopefully he/she can prescribe some drugs to help you deal with your symptoms.
> > > I hope you feel better soon,
> > > Kat
> > >
> > >
> >
> > Sorry that doesn't make sense. I was on 45 mg of Nardil for 8 weeks and it was the same after 3.5 weeks. I never ramped up the dose. I started at 45 mg the entire time. If I go lower, I don't see why 45 mg wouldn't work exactly the same.
> >
> > If you're saying it needs to be rapidly increased to help me, then no way. Because I was doing fine on 45 mg, and 4-5 days after I start 60 mg I started getting more depression. I expected side effects, but I shouldn't have more depression.
> >
> > MAOI work by getting the RIGHT LEVEL OF MAO. TOO MUCH MAO OR TOO LITTLE CAUSES ISSUES. Mental health is not about just going to extremes, it's about balancing it out correctly.
> >
>
> I think she means that once you went up to 60, a maintenance dose of 45mg might keep you at the same level of MAO inhibition as you have less MAO to metabolize the Nardil. Maybe try dropping down to 30 until side effects subside and then bringing it back up?
>Thanks Endub, for clearing that up. I'd like to add that I in no way meant you should up your dose anymore and definitely not quickly. That's just something some docs do. I agree with Endub, that maybe you need to go to 30mg until you become stable and are able to increase the dose....and be sure to increase it very slowly. Again, I highly suggest you speak with your doctor and see what he/she has to say...not everyone can tolerate Nardil, and everyone has different doses that work best for them. Plus he/she can perhaps give you something to help with the bad side effects you are experiencing.
Kat
poster:ChicagoKat
thread:1026129
URL: http://www.dr-bob.org/babble/20120912/msgs/1026246.html