Posted by SLS on September 20, 2012, at 1:09:40
In reply to Two questions about Serotonin syndrome., posted by schleprock on September 19, 2012, at 21:44:22
> 1. Has anyone here actually had it.
Yes.
> What are the most common symptoms that one can know are unmistakebly SS related and not side-effects or an exacerbation of mental illness.
Incoherence, muscle rigidity, hyperpyrexia.
> And most importantly, what do you do when you know you have it? Go straight to the ER or merely self-unmedicate the offending medicine.
That's a tough call. First of all, you would not be able to get yourself to the ER because of the effects of the syndrome. Your doctor can prescribe some cyproheptadine (Periactin) as an emergency treatment.
> 2. Does SS occur exclusively from the mixture of more than one serotonin-acting drug, or is it possible to experience it from a particular dose (or overdose) of a single drug?
Single drugs can precipitate SS, too.
Serotonin syndrome is inconsistent and unpredictable. Even Remeron has been reported to precipitate SS when added to an SRI.
- Scott
-------------------------------------Mental status changes
Confusion (51%)
Agitation (34%)
Hypomania (21%)
Anxiety (15%)
Coma (29%)Cardiovascular
Sinus tachycardia (36%)
Hypertension (35%)
Hypotension (15%)Gastrointestinal
Nausea (23%)
Diarrhea (8%)
Abdominal pain (4%)
Salivation (2%)Motor Abnormalities
Myoclonus (58%)
Hyperreflexia (52%)
Muscle rigidity (51%)
Restlessness (48%)
Tremor (43%)
Ataxia/incoordination (40%)
Shivering (26%)
Nystagmus (15%)
Seizures (12%)Other
Diaphoresis (45%)
Unreactive pupils (20%)
Tachypnea (26%)
Hyperpyrexia (45%)
-------------------------------------Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1026170
URL: http://www.dr-bob.org/babble/20120912/msgs/1026191.html