Posted by AlexCanada on September 14, 2012, at 23:02:03
In reply to Re: is a GABA antagonist what i need? » AlexCanada, posted by phidippus on September 13, 2012, at 23:27:33
> >Do you have any other possible sources?
>
> http://www.ncbi.nlm.nih.gov/pubmed/17545748
>
> >The dopamine based medications you mentioned are >they generally fine to take if I stay on ritalin?
>
> Yes, in fact they tend to have a synergistic effect when taken with stimulants. I took Requip with Vyvanse for almost a year and it was a couple weeks into taking the Requip that I noticed my mood and motivation had significantly increased moreso than when taking Vyvanse alone prior.
>
> Between the two, Requip and Mirapex, I would recommend Mirapex. It has a lot more data backing its efficacy at treating depression.
>
> I too suffer from anhedonia during periods of depression, so I can relate. Of all the drugs I've tried to treat it, Buprenorphine was the most succesful, but had the most side effects, unfortunately.
>
> What is your diagnosis and what drugs doo yoou take?
>
> EricMy diagnosis is erroneous. My doctor thinks I may have bi-polar even though I've never been manic or exhibited any of the symptoms. He happened to once see me during a time when I was taking a lot of gingko biloba and protein powder and was able to be interested in one thing in my miserable life... sex, so he felt it must have somehow been possible. Whatever. He also feels it might just be unipolar but me and him have been able to basically agree upon Melancholic Depression from my own research. I shouldn't have to do this. Doctors should know the symptoms but he is one of the very few doctors who will bother to listen to me.
At the bottom of this post I'll paste my symptoms in greater detail along with what I have tried. Basically almost all melancholic symptoms can be applied to me. Also I deal with some anxiety issues. Anxiety which manifests itself out of nowhere. it is less prominent these days than years ago. Zoloft is compounding my poor cognition and making me feel emotionally numb and very dull.
Right now i'm on valium 2.5mg 4x a day (around), ritalin 2.5 mg 4x a day (around), Zoloft 25mg a day (day 8 on it), 250mg Rhodiola Rosea, stopped Magnesium Glycinate recently (caused anxiety at times), stopped Vit D3 recently, Sometimes I take Gapapentin for short term relief of many symptoms, Once in a while I take modafinil if I really need energy and productivity but it usuaully causes me to feel lousy after 5 hours, sometimes even dysphoric.
Below are my symptoms and meds I have tried...
Biggest Issues: Severely poor long term memory and ability to retain new knowledge, Antero Grade Memory Loss, Poor Cognition, Lack of emotions, Anhedonia, Dysphoria, Mind feeling blocked/cloudy, Severe lack of enjoyment, Lack of drive/motivation/desire/sense of reward, Difficulty relating to others and feel bit like a zombie, Severe difficulty being social (also partially due to inability to relate), Anxiety (usually handled if I keep taking valium), Low energy
Effects of Memory and Cognitive Issues: Loss of current thought process and forgetfulness of what I was about to do, Forget what happened a day ago, people's names, difficulty imagining what people's faces look like, unable to recall events from tv shows/movies/media, slow speech usually, takes time to process thoughts and information,
Best Medications tried: Ritalin/Dex (especially first time), Parnate (first few months especially), Paxil (some resemblence of normalicy and integration into society). Valium/Ativan (some mood improvement + anti-anxiety), Gabapentin (Improvement of most symptoms including emotions and cognition, but tolerance builds quickly). Vivalan/Vivarint (only available in france now),Treatments Tried:
Benzo- Valium, Ativan, Klonopin, Xanax
SSRI- Celexa, Paxil, Zoloft,
SNRI/Other/Alternative- Wellbutrin, Effexor, Stablon, Remeron, Lithium, Adrafinil, Gabapentin, Narproxen, Vivarint, Buspar, Trivistal LA, ECT, rTMS, Reboxetine, Mirapex,
NRI- Reboxetine,
MAOI- Parnate, Nardil
Stimulant- Ritalin, Dexedrine, Provigil
Anti-Psychotics- Zyprexa, Risperidal, Abilify (as a low dose add-on), Seroquel,
Natural/Herbal- Rhodiola Rosea, Omega 3, Omega Complex, Korean Ginseng, Magnesium Glycinate, Royal Jelly, Niacin, Gingko Biloba, Bee Pollen, L-Arginine, Resveratrol, D3, Maca Root,Sensitivities: Vitamin A, Sunlight,
----Treatment Results:
Worse: Celexa (gradual worsening of depression and burning pain), Effexor (rapid worsening of depression and burning pain), Abilify (rapid worsening of depression when taken w Parnate), Cymbalta (gradual worsening of depression), Seroquel, ECT (Severely damaged my long term memory and overall cognition perminently), Nortriptyline, Lithium,
Better: Risperidal (some ability to enjoy things but overall would still be largely lacking), Parnate, Ritalin (first time this or Dexedrine was taken I was able to feel a bit like my old self, ability to experience pleasure, positive outlook, return of old hobbies, Was able to appreciate being alive), Dexedrine (similar to ritalin), Valium (some mood improvement, some anxiety improvement, most benzos have had similar effect), Ativan (was more social on this than other benzos while also on Paxil), Rhodiola Rosea (herbal similar to an MAOI) (A small miracle for mood, energy, cognition, general well being, would still be lacking pleasure. Has lost much effect over time), Gabapentin (tremendous cognitive improvement, imagination, more emotions, less cloudy thought process, feeling of greater intellectual capacity. Some improvement to mood, ability to be social. Although rapid tolerance onset, inconsistent, ironically sometimes cognitive impairment.), Vivarint (some mood improvement, massive improvement to sex drive),
Mixed Results: Remeron (sluggish on low doses, more active on higher doses, very mild mood improvement, impulsive spending), Zyprexa (some mood improvement, lot of lethargy, cognitive slowness, food tasted wonderful), Stablon, Modafinil (increased Cognition, Energy, Motivation but may compound dysphoria)
Negligible or Unsure: Zoloft, Nardil, Adrafinil, Narproxen, Buspar, rTMS (could not access any tangible improvement), Reboxetine, Mirapex, Piribedil, Klonopin, Wellbutrin,
Needs confirmation (not sure if taken): Prozac,
poster:AlexCanada
thread:1025108
URL: http://www.dr-bob.org/babble/20120912/msgs/1025679.html