Posted by phidippus on September 13, 2012, at 22:57:52
In reply to Re: Benzo when changes from feel good to tired?, posted by Phillipa on September 13, 2012, at 20:43:10
Benzodiazepines are fat soluble and do enter fatty tissues including the brain. But these tissues are in equilibrium with the blood, so that if the concentration in the blood is lower than that in fat, some will come out of the fat and re-enter the blood where it is metabolised and excreted. This will again lower the blood concentration, so more will leach out of the fat, and so on. So the body is more or less cleared, even of long half-life benzodiazepines, within 30 days. There is no evidence that benzodiazepines are "locked up" in tissues for years.
Eric
poster:phidippus
thread:1025502
URL: http://www.dr-bob.org/babble/20120912/msgs/1025621.html