Posted by brynb on September 13, 2012, at 22:40:59
In reply to Addiction Proof Pain killer, posted by zazenducke on September 12, 2012, at 16:59:51
> Interesting article about an enantiomer of naloxone. Do you think people whose depression lessens on opiates would still feel relief if the pleasure producing effect was blocked and they were only recieving pain relief? Only testing in ratties of course.
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Very interesting! I'm not great at sifting through all the neuroscience, but a doctor friend of mine who used to be a psych doc and addiction and pain med specialist (he's no longer practicing, he's a professional musician now) had told me that pain patients (be it physical or psychic pain) don't experience the same "high" that others would.He said that in his experience, the people who get the most "kick" out of opioids are people who are mostly not in chronic physical or mental pain. He said that pain meds affect "normals" and the painful VERY differently. For example, pain antagonizes the respiratory depression effect of high opioid doses, and dose can be raised almost geometrically per hour as long as acute pain exists.
So basically, in theory, or at least in my friend's opinion, it should still be effective despite not producing euphoric effects.
I take Tramadol (hardly an "opiate" but a weak opioid nonetheless). I never get "high" or euphoric from it, just a brightening in mood and motivating effect.
Thought I'd chime in and add my two cents.
-b
poster:brynb
thread:1025514
URL: http://www.dr-bob.org/babble/20120912/msgs/1025617.html