Posted by linkadge on September 12, 2012, at 8:25:49
In reply to flumazenil is probably acutely neurotoxic, posted by iforgotmypassword on September 11, 2012, at 2:38:31
flumazenil will reverse tolerance to benzodiazapines, (or at least reduce the acute effects of benzodiazapine overdose).
The problem is that flumazenil is not selective for the nucleus acumbens - it is going to antagonize benzodiazapine receptors in all brain regions.
flumazenil treatment would be about as pleasurable as benzodazapine withdrawl.
iirc, you were convinced that you hand some sort of dopamine depletion or something. Well, cyprohepdadine has many actions. Yes it is a 5-ht2c angagonist, but (believe it or not) also shows some antipsychotic like effects. It is also an antihistamine, 5-ht7 antagonist, calcium channel blocker etc.
Lets just say your problem was different. Lets suppose you have genetic dysfunction with your calcium channel receptor - gene which has been linked to anhedonia. So, cyproheptadine is really working because it is a calcium channel blocker.
Now, you decide your problem will be solved with a benzodazapine antagonist. If your problem was due to overactive calcium channels, flumazenil will send you into a tailspin.
I agree completely with you that doctors fall way too short in understanding depression in many patients, but that being said....a little knowledge can be a very dangerous thing.
I certainly have only caused myself more damage through years of feeling around in the dark with this or that theory.
But.....be as you will.
Linkadge
poster:linkadge
thread:1025108
URL: http://www.dr-bob.org/babble/20120912/msgs/1025487.html