Posted by SLS on August 23, 2012, at 20:02:07
Vortioxetine is currently in Phase III. I like the way this drug looks.
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"Dual mechanism of action
Vortioxetine displays two complementary mechanisms of action in vitro: inhibition of serotonin reuptake and modulation of serotonin receptor activity. In addition to blocking the serotonin transporter protein, vortioxetine acts as antagonist at 5-HT3 and 5-HT7 receptors, a partial agonist at 5-HT1B receptors and an agonist at 5-HT1A."
http://www.mims.co.uk/news/1132799/new-multimodal-antidepressant-effective-elderly/
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"Vortioxetine (previously known as Lu AA21004) is under investigation as a multimodal anti-depressant that is thought to work through a combination of two complementary mechanisms of action: receptor activity modulation and reuptake inhibition. In vitro studies indicate that vortioxetine is a 5-HT3 and 5-HT7 receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the serotonin transporter (SERT). In vivo non-clinical studies have demonstrated that vortioxetine modulates neuronal firing and neurotransmitter release in multiple systems, resulting in enhanced levels of serotonin, noradrenaline, dopamine, acetylcholine and histamine in specific areas of the brain.
The multimodal activity profile of vortioxetine may translate into therapeutic benefits in depression that current therapies do not sufficiently address."
http://investor.lundbeck.com/pipeline.cfm
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- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1024063
URL: http://www.dr-bob.org/babble/20120818/msgs/1024063.html