I think that an increase in synaptic concentrations of serotonin can have variable effects, depending on the extant balance of 5-HT receptors and the routing of the circuits they modulate. Lexapro can produce anxiety as well as quell it, depending on the individual taking it. Quite often, Lexapro increases anxiety early in treatment (about day 14) and decreases it thereafter. Prozac can produce anxiety in some people and not in others. Perhaps this is the result of interindividual differences in the sensitivity of 5-HT2c receptors. Glutamate can be excitatory upon dopamine circuits or inhibitory upon them, depending on what brain structure is being acted upon. It might excite certain structures in the dorsal striatum, but inhibit others in the ventral striatum (nucleus accumbens).
- Scott
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this signature | Show by default | Change to hide (next time)Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw