Posted by SLS on August 11, 2012, at 20:04:31
In reply to Re: Long term efficacy of antipsychotics, posted by schleprock on August 11, 2012, at 18:36:49
Just a few points:
Latuda also antagonizes 5-HT7 receptors. There is some indication that this property promotes an antidepressant effect.
As is the case with the other "atypical" neuroleptics, risperidone is a potent antagonist of 5-HT2a receptors; an action that can increase dopamine activity in the PFC. I would not discount the potential for risperidone to produce antidepressant effects, especially in combination with SRIs. It did for me, although not for very long. I was taking Parnate at the time.
If I am not mistaken, all of the DA antagonist antipsychotics increase the presynaptic synthesis and release of dopamine. Of course, the postsynaptic neuron is usually "blind" to this increase of synaptic dopamine because its receptors are being blocked by the drug.
I found that Neurontin produced some improvement in my depression. It lasted for less than a week, though. After discontinuing Neurontin, I was left in a dysphoric fog for over three weeks. I reacted to Lyrica in exactly the same way. It was very scary. I feared that I would be stuck in that state indefinitely. In the future, I will try to avoid any drug that acts to inhibit the alpha2delta subunit of the calcium channel. I am guessing that, for some people, the ability of these drugs to accelerate glutamate reuptake produces an anxiolytic effect.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1022971
URL: http://www.dr-bob.org/babble/20120803/msgs/1023073.html