Posted by SLS on August 5, 2012, at 2:27:46
In reply to Re: another question SLS - sorry!!!! » phidippus, posted by g_g_g_unit on August 4, 2012, at 19:38:38
> > >it only seems to help until 5pm or so
> >
> > Klonopin has a 18 hour half-life. I htink what you're experiencing in the afternoon is psychological.
> >
> > Eric
>
> Another explanation would be that Parnate has a 2.5 hour half-life, which means it would assume a cumulative effect throughout the day (when dosed every 3 hours), potentially resulting in peak stimulation during the afternoon.It is possible that this effect is less a matter of the accumulation of Parnate in the blood and brain tissues and more the peaking of MAO inhibition. I guess it makes sense that any stimulation effected by the Parnate molecule itself would be amplified by the increase in enzyme inhibition and an attendant rise in catecholamine release. You could try dosing every three hours throughout the day to see if this schedule mitigates these side effects. At some point, you might be able to consolidate your dosings again as the stimulant reaction ameliorates on its own.
You can do this.
Good luck.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1022549
URL: http://www.dr-bob.org/babble/20120803/msgs/1022749.html