Posted by bleauberry on August 2, 2012, at 17:53:47
In reply to miraprex, posted by idelle on August 1, 2012, at 17:22:07
There is actually more literature out there on this topic than I thought, but in the real world I think I only remember a few people who tried mirapex. Generally the impression I got was that it fit one of these scenarios.
It felt good for a short time but pooped. Difficult withdrawal. Sleepiness. Made depression worse. I can't recall anyone claiming it was a great med for them and lasted quite a while. Though I am sure it does happen. My own opinion is it would have its best effect when combined with other strategies that also hit serotonin and/or norepinephrine. An ssri for example could be problematic or ineffective for a patient, but with something like mirapex added, it could all come to life. I think that happens fairly often with abilify added to ssri, and though abilify is an antipsychotic it has some agonist activity also.
When I was in the hospital in the psychiatric ward I told the doc I had tried everything imaginable except dopamine agonists. So while I was there I got to try two different ones, including mirapex. To me they felt bad and I can't imagine how anyone can handle them for parkinsons. I thought antipsychotics made me feel sort of numb and tired and that a dopamine agonist would do the opposite but I was wrong because with me it made me even more tired and more numb and more depressed too. I think with the dopamine system there are 3 different types of people....normal dopamine function, hyper dopamine function, and hypo dopamine function. That's why a dose of amphetamine might make one person feel like they drank 5 pots of coffee, yet with someone else will calm them down so they can focus and concentrate. So back to mirapex, who knows. A personal trial would be needed to answer the question, and even then, it only pertains to that person. Could be a bust and could be a miracle.
poster:bleauberry
thread:1022573
URL: http://www.dr-bob.org/babble/20120718/msgs/1022635.html