Posted by SLS on July 30, 2012, at 7:38:35
In reply to Re: Abilify and dopamine release » TRD_12, posted by SLS on July 30, 2012, at 7:08:01
> Lamictal seems to prevent dopamine depletion.
Do you have more information on this?
With regard to the dynamics of dopamine activity in the nucleus accumbens, I am guessing that it is increased by Lamictal through the disinhibition of DA circuits via thalamic glutamate release inhibition rather than by preventing some sort of "depletion". I don't think that it is depletion that reduces limbic hypoactivity. It is probably the result of some dysfunction upstream - perhaps a reduction in NE activity prefrontally. I don't really know. My pet theory might be wrong, but I haven't yet seen a better explanation for the dopaminergic properties of Lamictal.
http://www.dr-bob.org/babble/20080606/msgs/833971.html
I don't even know what is meant by "dopamine depletion". How does it occur?
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1022353
URL: http://www.dr-bob.org/babble/20120718/msgs/1022418.html