Posted by SLS on July 17, 2012, at 6:04:08
In reply to Re: Zoloft 200mg not working. Scared + need advice!, posted by bleauberry on July 17, 2012, at 5:27:52
> At this stage of the game.....10 years into ssri's...I seriously doubt any single ssri by itself is going to be of any use to you. However, partner it with a TCA such as Nortriptyline, and it's a whole new world of opportunity. With that in mind, I do not like the abilify idea or the luvox idea, waste of time, but I do like the anafranil idea. It's just easier and cleaner to get a similar effect by combiining zoloft with nortriptyline.
Do you dislike the Abilify idea for this case only, or as a general rule? There are scores of people out there with depression who find Abilify to represent the difference between drug failure and complete remission. Abilify helps me more than Anafranil did. I don't think Abilify is a waste of time. Then again, any drug is a waste of time if it doesn't work for the specified individual right?
If you see Abilify as being a waste of time in this particular case, I would greatly appreciate it if you would list your reasons for believing such. Do you feel that there is a certain set of symptom clusters that indicates a failure to respond to Abilify as an augmenting agent? I imagine there are, but I have never thought about it.
Perhaps: non-melancholic, anhedonia, anergia, hypersomnia, loss of interest and motivation, loss of libido, and cognitive slowing among others? Even if one identifies such a relationship, there are bound to be cases that fall outside these parameters who will also benefit from Abilify just as there will be some falling within the parameters who are unresponsive to it.
At this point, I still like Stephen Stahl's characterization of Abilify as being a dopamine system stabilizer (DSS).
Personally, I never excluded a drug from consideration when seaching for something that works for me. I will, however, list potential treatments in an order of priority base upon clinical observations and hypotheses both. However, I think clinical observation trumps theory. Clinical observation indicates that Abilify is effective as an adjunctive medication for treating MDD and BD depression.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1021540
URL: http://www.dr-bob.org/babble/20120630/msgs/1021589.html