Posted by psychobot5000 on June 28, 2012, at 18:22:39
In reply to Augmenting geodon with risperidone, what dose?, posted by psychobot5000 on June 28, 2012, at 13:38:21
> Hi,
>
> Currently taking a low dose of geodon/ziprasidone: 10mg twice or three times per day. Larger doses are no more effective (but exacerbated OCD). It's been suggested I try to improve my antidepressant response by adding risperidone. I suppose the theory would be that the numbers are a bit better for risperidone on binding affinity for 5HT-2a vs D2 and 5HT-2c (i.e. with risperidone you can get somewhat more 5HT-2a blockage without affecting the other receptors). However, risperidone's effects on the 5ht-1 system are less useful (if I remember correctly, geodon is a 5HT-1a and 1d AGONIST, which, combined with 5ht-2a blocking, may be a good antidepressant combination. Risperidone, in contrast, is a 5-HT-1a blocker).
>
> Anyone have an idea what dose of risperidone might be optimal to get good antidepressant effects out of it in combination with low-dose ziprasidone/geodon? .5mg? .25mg?
>
> Thanks,
> PB5000
Followup: here are relevant links--a presentation on the use of AAPs for the affective and cognitive symptoms of schizophrenia:
http://www.medscape.org/viewarticle/484929And a detailed table for antipsychotic binding affinities:
http://www.nature.com/npp/journal/v28/n3/fig_tab/1300027t1.htmlRemember, the goal would be (I think) to hit 5ht-2a with risperidone, while largely sparing 5ht-1a and probably 5ht-1d.
poster:psychobot5000
thread:1020331
URL: http://www.dr-bob.org/babble/20120608/msgs/1020360.html