Posted by SLS on June 14, 2012, at 8:17:23
In reply to Re: SLS.. An awsome xenobiologic that U DONT KNOW ABOU » SLS, posted by novelagent on June 14, 2012, at 7:38:57
> > I bet cariprazine and Abilify display some potential for treating cocaine addiction - much like buprenorphine aids in the treatment of heroin addiction. The key here is partial agonism at the relevant receptors; D2/D3 dopamine receptors for cocaine and µ opioid receptors for heroin.
> >
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> Abilify increased meth use in one study...Do you recall where you saw this?
> beyond that, it's typically weak.
In what respect? Pharmacologically, Abilify is a potent D2/D3 receptor ligand, having a high binding affinity. If you are referring to its potential to effectively treat schizophrenia, I haven't investigated it. However, I am not sure it would be the best choice when positive symptoms predominate. That is just a guess, though. For bipolar disorder, the combination of Abilify and Lamictal provide greater prophylaxis against relapse than either drug alone (as detailed in the current NIMH Bipolar Network Newsletter).
> The literature typically lists a host of meds that do nothing,
Shhhh. Please don't let my poor brain find out this secret. I wouldn't want to jeopardize my current placebo response to it.
Seriously, I would be very interested to see the literature that you allude to.
My comments about Abilify and addiction were limited to cocaine use, not amphetamine use:
http://www.ncbi.nlm.nih.gov/pubmed/21524261
There is this, though:
http://www.ncbi.nlm.nih.gov/pubmed/21373790
Obviously, there is not yet a consensus regarding the potential for Abilify to treat cocaine use. However, that Abiify can blunt the effects of cocaine is not questioned.
Another way to blunt the effects of psychostimulants and cocaine is to administer prazosin.
I think we are in agreement that paper theories are often of little value when evaluating the utility of psychotropic drugs.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1019274
URL: http://www.dr-bob.org/babble/20120608/msgs/1019708.html