Posted by Tomatheus on April 11, 2012, at 16:18:11
In reply to Re: Article on telomere length in depression, posted by linkadge on April 11, 2012, at 14:56:47
> I would assume that the depresson causes the shortening vs. the other way around.
>Linkadge,
I think that you could be right. One of the studies that examined the relationship between telomere length and depression (Wolkowitz et al., 2011) found telomere length to be inversely correlated with lifetime depression exposure. Another study (Elvsashagen et al., 2011) found the "load of short telomeres" to be associated with the lifetime number of depressive episodes in patients with bipolar II disorder. The authors of the first study that I cited concluded: "These preliminary data indicate that accelerated aging at the level of leukocyte telomeres is proportional to lifetime exposure to MDD. This might be related to cumulative exposure to oxidative stress and inflammation in MDD. This suggest that telomere shortening does not antedate depression and is not an intrinsic feature. Rather, telomere shortening may progress in proportion to lifetime depression exposure."
Tomatheus
==
REFERENCES
Elvsashagen, T., Vera, E., Boen, E., Bratlie, J., Andreassen, O.A., Josefsen, D., et al. (2011). The load of short telomeres is increased and associated with the lifetime number of depressive episodes in bipolar II disorder. Journal of Affective Disorders, 135, 43-50. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21880373
Wolkowitz, O.M., Mellon, S.H., Epel, E.S., Lin, J., Dhabhar, F.S., Su, Y., et al. (2011). Leukocyte telomere length in major depression: Correlations with chronicity, inflammation and oxidative stress - preliminary findings. PLoS One, 6, e17837. Abstract: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017837
Dx: schizoaffective disorder
Taking Abilify and 4 supplements
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