Posted by leslieg on April 2, 2012, at 23:44:05
In reply to Re: SLS et al...combining stim with antipsychotic » rjlockhart04-08, posted by Shes_Initforthemoney on March 28, 2012, at 14:11:04
> > Im not SLS but I have taken Dexedrine Spansules 2 years ago with 10 Zyprexa and Xanax 2mg. It was a vary relaxed stimulation, the motivation to get up and clean wasnt as pronounced as Dexedrine taken by itself.
> >
> > It has a synergy effect. Vary similar to barbituate/amphetamne combos
>
> Hey RJ...that is okay, I want anybody/everybody possible to respond if they can. (Don't we all?..lol)
>
> My main problem is with the apathetic symptoms that comes with most antidepressant use. I just recently bumped my Effexor dose to 150mg, thinking it would tinkle the norepinephrine pathways, but it caused way too much cognitive blunting and overall apathy. (I have been on Effexor up to 475mg's before...this trial I am talking about was to see if the apathy could be avoided with the con-current use of other meds.)
>
> I have talked with my doctor about me possibly having some schizo-effective (mostly) negative symptoms. I respond to antipsychotics quite well, with the exception of Zyprexa because it blasts my blood sugar way wayyy too high..and I feel sick and ill when that happens.
>
> But, my main med is Prozac, even if it invokes some anxiety and apathy. I can't tolerate any other SSRI's or antidepressants. (Ohh..with the exception of Celexa..but that med is still not powerful enough to help my depression.)
>
> So, I continue my experimentation, because I refuse to let this illness take any more life away from me. I also had a cool reaction to a small dose of Oxycontin and Celexa before, too. But, I have never "craved" to have that combination again, though.
>
> So, my experiment (a work (jerk?..hahahh) in progress..lol) continues. Hope you are doing well RJ.
>
> Best,
> Jay
>
>
I may be way off-base here because I don't know what SLS is, but this post really caught my eye because I've been having post-stim (Vyvanse/Dexi) side-effects that I thought I might be able to blunt w/ an antipsychotic (Abilify) but when I Googled I found that antipsychotics (typical and not?) reduce dopamine levels so I worry that even though I feel like an antipsychotic is exactly what I need, it may be exactly what I *don't* need. So I'm curious about further input to your question!
I do wonder if you still have a lot of depression after trying all SSRIs if perhaps you have soft bipolar? I had a suicide attempt while on the "best" SSRI we'd found and I decided to never do SSRIs again. I tried Lamictal but was too afraid of it, then Tegretol which was OK but I wasn't too happy with, then back to Lamictal which gave me the least-depressed winter I've had in a long, long time. But then the depression hit *hard* a month or so ago and in desperation I've added a bit of Tegretol -- and it seems to be making a good difference. (The 2 together change dosaging AND I switched to genenric so it has taken a bit to figure out how things will settle down!) ... My days are generally good, the Lamictal had caused too much apathy, the Tegretol seems to be reducing that. Nights are when the anxiety sets in but I think that is from lack of dopamine (I've been on stims a long time -- narcolepsy.) Even that has been improving a bit.
... But a huge difference between you and me is that I can't tolerate meds that mess with my norepi system. Effexor being just one of them.
... Such a huge but important puzzle to try to solve ...
Good luck,
Leslie : )
poster:leslieg
thread:1014222
URL: http://www.dr-bob.org/babble/20120328/msgs/1014812.html