Posted by psychobot5000 on March 26, 2012, at 23:00:12
In reply to anyone with Clonidine experience?, posted by g_g_g_unit on March 26, 2012, at 20:46:07
> I've read that Clonidine is a selective alpha-2 agonist that's capable of both suppressing and stimulating noradrenaline release at different doses. I'm also aware that it has an extremely long half-life (Wikipedia says 12-33 hours?).
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> I really can't tell what effects I can attribute to it. It helps with sleep onset (0.2-0.3mg), but I don't sleep particularly well. I also find that the next day, I feel a little blunted in certain respects - I'm less irritable and also feel less physically anxious but at the same time kind of 'dead'. Is it usual to expect some carryover effect into the next day?
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> As for its interactions with Parnate, it's hard to say. As I've mentioned, there's a blunting of physical stimulation, but I can't really tell what effect it's having on the mental stimulation-side of things. I feel kind of blank and overstimulated at times, which I tend to associate with too much noradrenaline, so either the Clonidine's not helping or potentiating that side of things?
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I have taken clonidine for anxiety, and your experience matches mine. In answer to your question: yes, it's usual to expect some carryover effect the next day.It was not useful for me. Made me feel fatigued and, as you describe, blunted and dead. I hated it so much that I didn't try guanfacine next, as Scott suggested, though it's probably a good idea to give that one a shot.
poster:psychobot5000
thread:1014119
URL: http://www.dr-bob.org/babble/20120316/msgs/1014137.html