Posted by Brainbeard on March 26, 2012, at 15:07:40
In reply to I don't think fluvoxamine is doing anything positi, posted by linkadge on March 18, 2012, at 14:04:52
Fluvoxamine can activate you for certain, but this is more usual for the start-up phase and shortly thereafter than for the longer term. Still, there are people who continue to sleep badly on it, which seems like one aspect of activation.
Fluvoxamine inhibits CYP 1A2 enzymes very strongly. This enzyme group metabolizes melatonin, the sleep hormone. So fluvoxamine slows down the break-down of melatonin, thereby increasing melatonin levels tremendously. Walking around with a lot of melatonin in the daytime can give one a very jetlagged feeling. The irritability could be caused by this chemical jetlag. It normally gets better or disappears with longer term use. Sitting in front of a bright monitor helps breaking down melatonin, really, as would light therapy.
Current meds: clomipramine 225mg, fluvoxamine (Luvox) 50mg, methylphenidate 30-90mg, flupentixol 1mg. PRN: oxazepam 5-20mg or other benzo's.
poster:Brainbeard
thread:1013394
URL: http://www.dr-bob.org/babble/20120316/msgs/1014085.html