Posted by SLS on March 13, 2012, at 0:57:13
In reply to SLS (Scott), anybody,,Clonidine (triggers), posted by Shes_InItForTheMoney on March 12, 2012, at 23:04:18
Hi Jay.
I just wanted to let you know that I saw your post. However, it is 1:37 am, and I should probably try to get back to sleep.
Clonidine = pre-synaptic NE alpha-2 agonist.
Prazosin = post-synaptic NE alpha-1a/b/d antagonist.Both drugs reduce NE activity. However, they act on opposite sides of the synapse. I was thinking that combining the two drugs would work particularly well for PTSD. I guess this would also improve sleep. Prazosin is not depressogenic as far as I know. Clonidine is depressogenic, but not for everyone. There is also propranalol to reduce sympathetic tone. It works well for some people to reduce the autonomic effects of anxiety. It is clonidine, however, that reduces cortisol release the most.
Gosh. I couldn't help myself.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1012935
URL: http://www.dr-bob.org/babble/20120302/msgs/1012944.html