Posted by bleauberry on February 22, 2012, at 4:24:32
In reply to Re: Linkadge, I could use your help., posted by linkadge on February 20, 2012, at 19:17:35
Very interesting. Most of the things I talk about often....inflammation, infection, toxins...have a common by-product....elevated glutamate.
> Hmm. Some of the things that come to mind are:
>
> Over-activation in parietal / occipital regions (a trait marker in familial depression)? Glutmate levels appear to be elevated even in non-depressed offspring.
>
> http://users.ox.ac.uk/~psyc0288/ray_page/int_j_neuropharm.pdf
>
> Low gaba (and hence elevated glutamate?) in the occipital lobes has also been found in other studies of depression. Gaba levels are elevated by successful SSRI treatment.
>
> http://ajp.psychiatryonline.org/article.aspx?Volume=161&page=368&journalID=13
>
> Glutamate has been shown to be elevated in the prefrontal cortex of depression and bipolar disorder. In stress induced models of depression, the prefrontal cortex appears particularly sensitive.
>
> http://www.medwire-news.md/56/71246/Depression/Glutamate_elevated_in_brains_of_mood_disorder_patients.html
>
> The only other regions that come to mind are limbic regions and as you mention Broadmann's area 25. The area 25 serves as kind of a gateway of the feedback loop between the prefrontal regions and limbic regions. I think some studies have linked depression to reduced volume in the cingulate area. The reduced volume might cause inefficient filtering of incoming stimuli and hence over activation of both regions.
>
> Linkadge
>
poster:bleauberry
thread:1011014
URL: http://www.dr-bob.org/babble/20120221/msgs/1011158.html